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Low Muscle Tone - Causes, Treatment and Effect to Overall Health

5/9/2018

2 Comments

 
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Low muscle tone in an infant or child is not a symptom to ignore. It can indicate significant pathology that is effecting the health of the child in other areas including brain development.
Signs and symptoms of low muscle tone:
  • Head lag
  • Fatigues quickly
  • Poor posture
  • Increased flexibility, increasing susceptibility to injuries
  • Poor persistence to gross motor tasks
  • Lack appropriate body awareness feedback
  • Avoids chewy foods
  • ​Feeding difficulties
  • Preference to engage in sedentary activities

An example of an infant with low muscle tone is seen in the video below. (This video may be difficult to watch but this exam is being conducted by a very experienced physician. We don't recommend that you attempt a head lag test on your own child with low muscle tone.)
Treatable Causes:
  • Hypothyroidism
  • Mitochondrial dysfunction
  • Methylation issues
  • Thiamine (B1) deficiency
  • Other B vitamin deficiencies
  • Carnitine deficiency
  • Creatine deficiency
Physicians should conduct a thorough physical exam that includes assessment of deep tendon reflexes, cranial nerves, eye movement, hearing, feeding, gross motor skills and general observation of the infant's movements. A physician trained in understanding the root cause of low muscle tone will also be able to detect signs and symptoms of other vitamin or nutrient deficiencies that are contributing to low muscle tone.
Dismissing low muscle tone in a child or infant with Down syndrome as simply caused by the presence of the extra copy of chromosome 21 will lead to a missed opportunity to detect a secondary treatable cause of low muscle tone. Negative consequences of low muscle tone are mostly seen as slow gut motility resulting in a vicious cycle that ultimately leads to nutrient deficiencies that further decreases muscle tone (Image 1). Another physical consequences of low muscle tone includes stressed joints. Malalignment of vertebral bones and subluxation can lead to further impairment of the nervous system, headaches and jaw pain.
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Image 1. Mechanism of nutrient deficiency in low muscle tone
Labs to be done in order to detect the underlying cause:
​
  • TSH, free T4, free T3, reverse T3
  • homocysteine 
  • acylcarnitine profile 
  • amino acids (plasma and/or urine)
  • organic acids in urine
  • creatinine

This is not an exhaustive list as there are many other labs to consider depending on the history and presentation of the patient.  Other labs to consider are vitamin D, ferritin, CBC and histamine. For more information about urinary organic acid testing please see our web page devoted to information about this very informative and important testing method: Organic Acid Testing. Naturally, lab results will guide appropriate treatment.

Physicians should be aware of all causes of low muscle tone and seek out appropriate testing in order to best treat it. Often children are referred for physical therapy and orthotic braces alone and no biochemical cause is pursued, especially when the child has a known genetic condition. While therapy and orthotics are often helpful they do not address the underlying cause of the low muscle tone. When any one of the causes listed above is missed this can greatly impact brain development, cognition and the overall health of the child. 
2 Comments
Valeria Campuzano
8/3/2020 10:15:51 pm

I have a child diagnosed with cp who also has a Bpi. Our neurologist mentioned his low muscle tone is hypotonia due to cp. Would it be worth it to run tests to find out his deficiencies in order to improve his diet hoping to see gains somehow? Thanks a lot.

Reply
Svetla Zibin
8/12/2020 08:37:03 pm

This is so interesting, thank you for writing this post and explaining. No one told us (nor I ever found information elsewhere) what could be the cause of low muscle tone. It was all “part of our son’s condition.

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    Dr. Erica Peirson

    Dr. Peirson is dedicated to helping children with developmental and learning challenges reach their fullest potential.

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