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MTHFR/MTRR

MTHFR Gene variants C677T, A1298C and association with Down syndrome: A case control study from South India.

Risk of Down syndrome conferred by MTHFR C677T polymorphism: Ethnic variations

Investigating the impact of the Down syndrome related common MTHFR 677C>T polymorphism in the Danish population.

MTRR and MTHFR polymorphism: link to Down syndrome?

MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome children.

Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome?

MTHFR 677C-->T and 1298A-->C polymorphisms in children with Down syndrome and acute myeloid leukemia in Brazil.

Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syndrome and congenital heart defects.

MTHFR 677 TT genotype in a mother and her child with Down syndrome, atrioventricular canal and exstrophy of the bladder: implications of a mutual genetic risk factor?

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China

Polymorphisms in Genes Involved in Folate Metabolism as Maternal Risk Factors for Down Syndrome

Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect.

Phosphatidylcholine

Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome

Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia.

A report on phosphatidylcholine therapy in a Down syndrome child

Learning behaviour and cerebral protein kinase C, antioxidant status, lipid composition in senescence accelerated mouse: influence of a phosphatidylcholine-vitamin B12 diet.


Vitamin E

Biomarkers of oxidative stress are significantly elevated in Down syndrome.

Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome.

α-Tocopherol supplementation reduces biomarkers of oxidative stress in children with Down syndrome: a randomized controlled trial.

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

Zinc

Nutritional status of zinc in children with Down syndrome.

Release of glutamate and GABA in the hippocampus under zinc deficiency.

History of zinc as related to brain function.

Effect of dietary zinc deficiency on ischemic vulnerability of the brain.

Is zinc deficiency a cause of subclinical hypothyroidism in Down syndrome?

Effect of omeprazole on plasma zinc levels after oral zinc administration

EGCG (Green Tea Extract)

EGCG prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome.

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.

Epigallocatechin-3-gallate - Full Study

Green tea EGCG plus fish oil omega-3 dietary supplements rescue mitochondrial dysfunctions and are safe in a Down's syndrome child.
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Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes.

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?


Glutamate

Glutamate as a Neurotransmitter in the Brain: Review of Physiology and Pathology

Peripheral markers of glutamatergic dysfunction in neurological diseases: focus on ex vivo tools.

Brain protein may play role in Down's syndrome

The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains.

Lithium

Lithium rescues synaptic plasticity and memory in Down syndrome mice.

Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome
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P.O. Box 20446
Portland, OR 97294

8100 W. Marigold St. #140611
Garden City, ID 83714