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Organic Acid Testing

The Organic Acid Test examines metabolites found in a patient's urine that are byproducts and intermediates of cellular and gut microbiome metabolism​. It can reveal imbalances in metabolic pathways, nutritional imbalances, mitochondrial dysfunction, urea cycle imbalance, oxidative stress as well as abnormal gastrointestinal microbial dysbiosis and malabsorption in the small and large intestines.  It's extremely useful for helping children with autism and Down syndrome. The organic acid test can help guide an experienced physician in making recommendations regarding diet, supplementation and other treatment.  ​
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Some believe that the biochemical, vitamin and nutritional needs are the same for every child with an extra copy of chromosome 21. This is not the case. They are all as beautifully unique as anyone else. There are many factors that contribute to the health, cognition and vitamin needs of these children and adults.  Some of these factors include the state of their microbiome and their other 45 chromosomes. The role the extra chromosome plays in biochemical processes within the body cannot be ignored, but must be combined with other aspects of physiology that contribute to health when determining supplements given to children.

​Below is a collection of resources to help parents and other practitioners when using this test for their child or patients.


Research (Pubmed)
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Role of plasma amino acids and urinary organic acids in diagnosis of mitochondrial diseases in children.


Noninvasive urinary organic acids test to assess biochemical and nutritional individuality in autistic children.

Urine amino and organic acids analysis in developmental delay or intellectual disability.


The In-Depth Evaluation of Suspected Mitochondrial Disease

Urine organic acid analysis for inherited metabolic disease using gas chromatography-mass spectrometry.

Urinary organic acids in infant malnutrition.

Application of metabolomics: Focus on the quantification of organic acids in healthy adults

Metabolomics of urinary organic acids in respiratory chain deficiencies in children

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Articles
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Using organic acids to diagnose and manage recalcitrant patients.

The benefits of an organic acid test


Clinical Applications of Urinary Organic Acids. Part 1: Detoxification Markers

Clinical Applications of Urinary Organic Acids. Part 2. Dysbiosis Markers

Organic Acids Simplified

Organic Acids in Central Energy Pathways


Labs
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​Genova Diagnostics

Great Plains Laboratory
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Interpretation Guides
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Interpretation and treatment: Organic acid – Energy and oxidative markers and treatment 

Organix Profile Interpretive Guide​

The Clinical Significance of the Organic Acids Test


Urinary Organic Acids
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Videos
Interpretation of the Organic Acid Test
Introduction to Organic Acid Testing - Part 1
Introduction to Organic Acid Testing - Part 2
This web site offers health, wellness, and nutritional information and is provided for informational purposes only. This information is not intended as a substitute for the advice provided by your physician or other healthcare professional. The use of any information provided on this web site is solely at your own risk. Nothing stated or posted on this website by The Peirson Center for Children are intended to be, and must not be taken to be, the practice of medicine. Information provided on this website does not create a doctor-patient relationship between you and any doctor affiliated with our web site. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease

©  2020. Peirson Center for Children. All rights reserved

P.O. Box 20446
Portland, OR 97294

8100 W. Marigold St. #140611
Garden City, ID 83714