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Thank you for considering participation in our study!
6/10/24 - We are no longer accepting applications at this time.
​We're excited to learn more about ways that we can help children with Down syndrome. 
Folate receptor alpha autoantibodies (FRAAs) are antibodies that either block or bind to folate receptors in the brain. The presence of these antibodies ultimately results in lower folate levels in the brain. Given the important role that folate plays in brain health and development the presence of these antibodies can have significant neurological implications. Recent research has revealed a high rate of the presence of these antibodies in children with autism as well as PANS/PANDAS (Pediatric Acute-Onset Neuropsychiatric Syndrome/Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections). 
Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorders: Diagnosis, Treatment and Prevention

Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population 
We are seeking to uncover the prevalence of these antibodies in children with Down syndrome as well as the role they may be playing in the comorbid conditions associated with Down syndrome like autism, seizures, sleep disturbances, speech delay, regression and others.

Participating in the study will involve:
  • A verbal assessment that will be conducted via teleconference before the study and at the end of the study
  • A blood draw of 2-4 mL of blood that can be included during your child's other routine blood tests if you choose
  • Giving your child Leucovorin daily, which is folinic acid and the standard treatment for positive FRAAs, if they are found to be positive for folate receptor antibodies

    Application

    If they have multiple diagnoses listed here please put them in the comments section below.
Submit
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8100 W. Marigold St. #140611
Garden City, ID 83714